Professional and Linguistic Assessments Board (PLAB) Practice Exam

Which TB drug has the potential to cause orange secretions in a patient?

1. Ethambutol

2. Rifampin

3. Isoniazid

4. Pyrazinamide

The correct answer is: Rifampin

Rifampin is known to cause orange secretions in a patient, which can include changes in urine, sweat, saliva, and even tears. This effect occurs due to rifampin's ability to alter the color of bodily fluids and is an expected side effect that patients should be informed about before starting the medication. It is important for patients to understand that while the color change may be alarming, it is a benign side effect and does not indicate an adverse reaction to the drug. Other tuberculosis medications such as ethambutol, isoniazid, and pyrazinamide do not typically cause a similar discoloration of bodily fluids, making rifampin the standout choice for this particular side effect.