Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What is the recommended treatment for Addison's disease?

  1. Hydro and fludrocortisone

  2. Levothyroxine

  3. Chlorpromazine

  4. Sitagliptin

The correct answer is: Hydro and fludrocortisone

Addison's disease, also known as primary adrenal insufficiency, occurs when the adrenal glands do not produce enough cortisol and, in some cases, aldosterone. The recommended treatment for this condition involves replacing the deficient hormones. Hydrocortisone, a form of corticosteroid, is prescribed to replace cortisol, thereby helping to manage symptoms related to low cortisol levels, such as fatigue, weakness, and weight loss. Fludrocortisone is a mineralocorticoid used to replace aldosterone, which helps regulate sodium and potassium levels, and maintain blood pressure. Together, these two medications effectively address both aspects of adrenal insufficiency in patients with Addison's disease. Other options provided are not suitable for treating Addison's disease. Levothyroxine is primarily used for hypothyroidism; chlorpromazine is an antipsychotic medication used for mental health disorders; and sitagliptin is an oral medication for managing type 2 diabetes. None of these options address the hormonal deficiencies associated with Addison's disease. Therefore, the combination of hydrocortisone and fludrocortisone is indeed the appropriate treatment approach.