Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What is one of the main benefits of using alpha 1 antagonists in treating BPH?

Decreased risk of urinary tract infections
Improvement in sexual function
Rapid relief from acute urinary retention
Reduction of prostate size

The correct answer is: Decreased risk of urinary tract infections

In the context of treating benign prostatic hyperplasia (BPH), one of the main benefits of using alpha-1 antagonists is the improvement in urinary flow and reduction of bladder outlet obstruction, which can subsequently lower the risk of developing urinary tract infections. Alpha-1 antagonists work by relaxing the smooth muscles in the prostate and bladder neck, leading to an increased urinary flow rate and decreased symptoms associated with BPH. This can also contribute to better bladder function, thereby reducing the likelihood of urinary stasis, a factor that increases the risk for infections. While other treatments may focus on altering prostate size or address acute urinary retention more drastically, alpha-1 antagonists specifically target the symptoms of BPH by improving urinary passage, indirectly contributing to lower UTIs due to improved voiding. Therefore, their role in managing urinary symptoms aligns closely with preventing conditions that could lead to infectious complications.