Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What is considered the universal blood type?

  1. AB+

  2. O-

  3. A+

  4. B-

The correct answer is: O-

The universal blood type is O-negative (O-). This designation arises from the lack of A and B antigens on the red blood cells of individuals with this blood type. Furthermore, O-negative blood lacks the Rh factor, meaning it can be safely given to patients of any blood type without causing an adverse reaction due to blood type incompatibility. This characteristic makes O-negative blood especially valuable in emergency situations where there may not be enough time to determine a patient's blood type. In contrast, other blood types, such as AB-positive or A-positive, contain specific antigens that could potentially lead to severe allergic reactions if transfused into someone who does not have those antigens. The absence of antigens in O-negative blood is what solidifies its status as the universal donor type.