Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What are common symptoms associated with SSRI withdrawal?

Headaches and insomnia
Diarrhea and vomiting
Weight loss
Anxiety and panic attacks

The correct answer is: Diarrhea and vomiting

The common symptoms associated with SSRI (Selective Serotonin Reuptake Inhibitor) withdrawal primarily include headaches, insomnia, anxiety, and panic attacks. These symptoms arise due to the abrupt discontinuation of SSRIs, which can lead to a sudden drop in serotonin levels in the brain that the body has adjusted to. Headaches occur as a result of changes in neurotransmission, while insomnia can be linked to the disruption in the serotonergic system, which plays a role in regulating sleep. Anxiety and panic attacks may emerge as the body's homeostasis is disturbed, causing heightened levels of stress symptoms. In contrast, diarrhea and vomiting are not typical symptoms of SSRI withdrawal. While gastrointestinal upset can occur with other types of medication discontinuation or reactions, it is not a hallmark of SSRI withdrawal. Weight loss is also not commonly associated with this type of withdrawal; rather, some individuals may experience increased appetite or weight gain depending on their emotional state and coping mechanisms during the withdrawal phase. Understanding these symptomatic patterns is essential for clinicians and patients to navigate the withdrawal process effectively and to prepare for any potential side effects when discontinuing SSRIs.